Zofran (Ondansetron): Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting - Clinical Evidence and Practice Guidelines

Product Monograph Brand Name: Zofran Generic Name: Ondansetron Hydrochloride Drug Class: Selective 5-HT3 Receptor Antagonist Therapeutic Category: Antiemetic Agent Manufacturer: GlaxoSmithKline (Original), multiple generic manufacturers 1. Introduction: What is Zofran? Its Role in Modern Medicine Look, I’ve been practicing oncology pharmacy for nearly two decades, and I can tell you without hesitation that Zofran changed everything. Before ondansetron hit the market in 1991, we were basically throwing metoclopramide and dexamethasone at patients and hoping for the best.