Promethazine: An Evidence-Based Review of Its Clinical Applications and Safety Profile

You know, when I first started seeing promethazine cases back in my early years at the county hospital, I thought it was just another antihistamine. Boy, was I wrong. This drug has a story that’s far more complex than most clinicians appreciate, and I’ve learned some hard lessons about it over the years. What Is Promethazine and Its Role in Modern Medicine Promethazine is a phenothiazine derivative with potent antihistamine (H1-receptor antagonist), antiemetic, sedative, and anticholinergic properties.