Naltrexone

Naltrexone: A Comprehensive Monograph on Opioid Antagonism and Beyond - Evidence-Based Clinical Review 1. Introduction: What is Naltrexone? Its Role in Modern Medicine Look, I’ve been prescribing naltrexone for nearly fifteen years now, and I still find myself surprised by what this drug can do. Originally developed in the 1960s as a pure opioid antagonist, naltrexone has evolved far beyond its initial purpose. It’s not just a medication—it’s a tool that fundamentally alters how we approach addiction medicine and, increasingly, autoimmune conditions.