The following monograph is based on the approved prescribing information for Metoclopramide (e.g., Reglan, Maxolon, Pramin) and current clinical guidelines. It is intended for educational purposes only. Metoclopramide: A Prokinetic Agent for the Management of Gastroparesis and Nausea - Comprehensive Clinical Review 1. Introduction: What is Metoclopramide? Its Role in Modern Medicine Metoclopramide is a unique, centrally and peripherally acting pharmacologic agent that has been a mainstay in gastroenterology for decades.