Kaletra (Lopinavir/Ritonavir): Antiretroviral Therapy for HIV-1 Infection - Comprehensive Clinical Monograph

1. Introduction: What is Kaletra? Its Role in Modern HIV Medicine Look, I’ve been prescribing antiretrovirals since the dark days of the early 90s when we were basically flying blind. Kaletra—lopinavir boosted with ritonavir—came along at a critical moment. It’s a protease inhibitor combination that changed how we managed HIV, particularly in treatment-naive patients and those with prior exposure to other PIs. Kaletra contains two active components: lopinavir (the actual active protease inhibitor) and ritonavir (a pharmacokinetic booster).