Doxylamine

Doxylamine: Clinical Profile of a Sedating Antihistamine for Insomnia and Allergic Conditions 1. Introduction: What is Doxylamine? Its Role in Modern Medicine Let’s be clear from the start: doxylamine is not a new drug, nor is it a particularly glamorous one. It’s an old-school first-generation antihistamine, specifically an ethanolamine derivative, that found its niche primarily as a sedative-hypnotic for short-term insomnia management. You know it best probably as the “PM” in over-the-counter sleep aids like Unisom SleepTabs or as a component in combination cold and flu products.