Azeetop: The Micronized Diosmin-Hesperidin Complex for Chronic Venous Insufficiency – Clinical Rationale and Real-World Outcomes Introduction: What is Azeetop? Its Role in Modern Medicine So you’re looking at Azeetop. Let’s cut through the noise. Azeetop is a medical device classified as a phlebotropic agent, specifically a micronized purified flavonoid fraction (MPFF) containing 90% diosmin and 10% hesperidin. It’s not a drug in the traditional sense—it doesn’t modify a disease pathway chemically.