Tofranil

Tofranil: Clinical Applications and Re-Evaluation of a Tricyclic Antidepressant in Modern Practice Introduction: What is Tofranil? Its Place in Contemporary Psychopharmacology Look, I’ll be straight with you. When I started my residency in the late 80s, Tofranil was king. We threw it at everything—depression, enuresis, panic attacks, chronic pain. These days? Most of my younger colleagues barely touch it. They reach for an SSRI like it’s candy. But here’s what I’ve learned after thirty-plus years of prescribing: Tofranil still has a seat at the table, and sometimes it’s the only chair that works.