Mysoline: An Evidence-Based Review of its Role in Epilepsy Management and Beyond

1. Introduction: What is Mysoline? Its Role in Modern Medicine Mysoline, the brand name for primidone, is an anticonvulsant medication that’s been around longer than most of my colleagues have been in practice. I remember when it was first-line for just about everything tremor-related and seizure-related. Times have changed, but Mysoline still holds a distinct, evidence-supported place in therapeutic arsenals. It’s a barbiturate analog, chemically related to phenobarbital, but with its own unique pharmacokinetic profile that makes it… well, interesting.