Compazine: Antiemetic Therapy for Nausea and Vomiting - Clinical Evidence Review

What is Compazine? Its Role in Modern Medicine So you’re looking into Compazine. Let me tell you what I’ve learned over 25 years of prescribing this drug. Compazine—generic name prochlorperazine—is a phenothiazine antipsychotic that found its true calling in managing nausea and vomiting. It’s been around since the 1950s, and honestly, it’s one of those old-school drugs that still earns its place in our arsenal. The drug comes in several forms: oral tablets (5mg and 10mg), suppositories (2.