Colospa: Comprehensive Evidence-Based Product Monograph

What is Colospa? A Spasmolytic Agent for Functional Bowel Disorders Colospa (mebeverine hydrochloride) is a musculotropic antispasmodic agent that’s been sitting in my prescription pad for over a decade now. It’s not new—first synthesized in the 1960s—but it keeps showing up in guidelines for irritable bowel syndrome (IBS) and other functional gastrointestinal disorders. The drug acts directly on colonic smooth muscle without the anticholinergic side effects that plague older agents like hyoscine or dicyclomine.