Apresoline: An Evidence-Based Review of Hydralazine Hydrochloride in Modern Cardiovascular Therapy

Introduction: What is Apresoline? Its Role in Contemporary Medicine Apresoline is the branded formulation of hydralazine hydrochloride, a direct-acting peripheral vasodilator that’s been kicking around since the 1950s. And honestly? It’s one of those drugs that refuses to die—not because it’s glamorous, but because it works when other things don’t. While newer antihypertensives like ACE inhibitors and ARBs dominate the guidelines, Apresoline maintains a stubborn foothold in resistant hypertension, pregnancy-related hypertensive disorders, and heart failure with reduced ejection fraction in specific populations.