Alprostadil: Comprehensive Clinical Monograph for Erectile Dysfunction and Vascular Applications

Let’s be clear from the start: this is not a supplement you buy at the pharmacy counter or order from an online wellness store. Alprostadil is a prescription-only pharmaceutical agent—specifically, a synthetic version of prostaglandin E1 (PGE1). In my practice, I’ve used it in two completely different contexts: as a vasodilator to keep a neonatal ductus arteriosus patent in critical congenital heart defects, and as an injectable therapy for erectile dysfunction (ED) when oral medications like sildenafil have failed.