Alli (Orlistat 60 mg): Evidence-Based Review for Weight Management in Overweight Adults

1. Introduction: What is Alli? Its Role in Modern Weight Management Let me be straight with you—when Alli hit the US market in 2007 as the first FDA-approved over-the-counter weight loss medication, I had mixed feelings. We’d been using prescription orlistat (Xenical, 120 mg) for years, and suddenly patients could buy a lower-dose version at CVS. The question was: would they use it responsibly? Alli is orlistat 60 mg, a reversible inhibitor of gastric and pancreatic lipases.