Wellbutrin

Wellbutrin: A Norepinephrine-Dopamine Reuptake Inhibitor for Major Depressive Disorder and Smoking Cessation - Evidence-Based Clinical Review Introduction: What is Wellbutrin? Its Role in Modern Medicine So you’re looking at Wellbutrin. Or bupropion, if we’re being precise. It’s not your grandmother’s antidepressant, and that’s exactly why it’s interesting. Most folks—patients and clinicians alike—think of SSRIs when they hear “depression medication.” But Wellbutrin sits in a completely different pharmacological neighborhood. It’s a norepinephrine-dopamine reuptake inhibitor (NDRI), which basically means it nudges two key neurotransmitter systems without messing much with serotonin.